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Another example of beneficial substitution is the inclusion of silicates, which increase the mechanical properties and accelerate the bioactive response of the hydroxyapatite (Vallet-Reg� and Arcos 2005).
1.4.2.1.7.3 Sol-Gel Glasses with Hydroxyapatite When the quick bioactive response of sol-gel glasses was observed, it rapidly inspired scientists to employ it as an additive in hydroxyapatite ceramics to accelerate the bioactive response (Oonishi et al. 2000).
In fact, with only 5% of bioactive glass with a com- position of 30% CaO-70% SiO2, the bioactive response of hydroxyapatite in SBF was noticeably increased from 45 days of immersion for pure hydroxyapatite down to 12 hours for the glass-hydroxyapatite mixture.
In terms of bioactivity, glass-ceramics are less reactive at their surface than pure glasses, which means a lower bioactive response.
In this sense, the inorganic content of the hybrids is commonly based on the SiO2-CaO system to ensure the presence of silanol groups at the surface and the leaching of calcium ions to the environment, which are well known to favor the bioactive response.
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